Endocrine Abstracts

A 29 year old lady presented to an outside hospital with 1 year’s history of episodes of confusion in the mornings. The patient’s partner had noticed that 2–3 times a week she awoke with episodes of confusion, minimal communication, stereotyped lip smacking and winking lasting up to 20 min. She had one nocturnal tonic-clonic seizure abroad, requiring A+E attendance. She was then seen by a neurologist, had a normal sleep deprived EEG and was diagnosed with focal ...

Introduction: Achieving an HbA1c of less than 48 mmol/mol minimises the risk of complications in children and young people with type one diabetes. Elective admissions to hospital are one option employed to improve glycaemic control in patients with an HbA1c above target. There is however limited evidence to support such admissions. We aimed to retrospectively compare glycaemic control between patients electively admitted to hospital to stabilise their dia...

Introduction: Premature ovarian insufficiency (POI) is a rare cause of primary amenorrhea (1,2). We report a 16-year-old girl with normal secondary sexual characteristics, but no menses due to an autoimmune POI and associated with autoimmune gastritis. This is the first report of such constellation in an adolescent – both conditions separately already being rare in the pediatric population.Case presentation: A 16-year-old girl was referred to our de...

Introduction: Turner syndrome (TS) affects 1/1700 female, is due to total/partial lack of an X chromosome and besides short stature and gonadal dysgenesis, is associated with several comorbidities. No defined psychiatric condition has been related to TS. However, several case-reports have appeared in psychiatric literature, and TS is reported to be three times more prevalent in schizophrenia compared with the general female population.Aim: To evaluate th...

: Sebaceous glands are very sensitive to androgens which can modify the size but not the number of sebaceous glands. Sebaceous hyperplasia is a common benign proliferation of the sebaceous glands seen during the first weeks of life, being reported in 89.4% of 1000 newborns enrolled in across-sectional prospective study in the period of November 2007 to May 2009 in India [1] or in 35% of 2938 neonates aged up to three days of life hospitalized in a Brazilian city [2]. Sebum sec...

Aim: The aim of the study was to evaluate the relation of vitiligo with thyroid autoimmunity.Materials and methods: A cross sectional study was done on 75 patients clinically diagnosed (old and new) with different types of vitiligo. Patients with known thyroid disease were excluded from the study. Serum TSH and anti-TPO antibodies were measured in all patients.Results: The prevalence of anti-TPO antibody positivity was found in 23 ...

We present three cases of females with low body weight that needed large amounts of anti-thyroid drugs – 4–5 mg/kg Thiamazole and 50 mg/kg of Propylthiouracil. First patient, aged 32, weight 45 kg, had Graves’s disease evolving for more than five years. She has been proposed surgery and needed 1200 mg/day of Propylthiouracil. She delayed surgery for 2 weeks, then the dosage required for euthyroidism was 1800 mg/day for three weeks. The goitre had 1.2 kg, from ma...

Introduction: Acromegaly is a rare chronic disorder caused by growth hormone hypersecretion due to GH-producing pituitary adenoma. Surgery is the first-line treatment modality. However, patients with severe cardiac involvement are high-risk candidates for pituitary surgery. These patients may benefit from rapid preoperative biochemical control of acromegaly. There is emerging evidence of efficacy of pegvisomant, a GH-receptor antagonist, (either alone or in combination with so...

Introduction: Despite being on adequate amounts of levothyroxine (>1.6 μg/kg) some patients still exhibit biochemical evidence of inadequate replacement (serum TSH >4.2 mIU/l±free-thyroxine (FT4) <12 pmol/l). We report the use of a 5-day absorption test for assessing levothyroxine absorption in such a patient.Case: A 35-year-old female with hypothyroidism since 2007 had a serum TSH ranging from 4.48 to 54.9 mIU/l and FT<s...

Primary Ovarian Insufficiency (POI) is an ovarian defect characterized by the premature depletion of ovarian follicles before 40 years and represents one major cause of female infertility. POI is a heterogeneous disease but, despite its idiopathic origin in most of patients, there is a strong genetic evidence, in particular for X chromosome-linked defects. BMP15 gene maps to Xp11.2 within a Turner locus critical for ovarian function and mutations in this gene have been found i...